YearZero is building a tissue-native platform to measure and model human uterine biology. The first application is in fertility.
YearZero combines native human tissue, high-resolution profiling, and computational modeling to build the Digital Endometrium — a model of uterine biology shaped by deep experience in reproductive and spatial biology.
The first application emerging from the YearZero platform, focused on implantation biology in IVF.
Fertility is a strong initial application: a defined clinical workflow, a measurable intervention window, and a major unmet need at exactly the step where better models of uterine state can produce meaningful translational outputs.
IVF provides a defined and measurable entry point — a window where uterine biology can be characterized, modeled, and acted on.
Implantation failure remains the primary bottleneck in IVF. The endometrium is undercharacterized relative to its clinical importance.
Every experiment run for the fertility application enriches the underlying platform. The first program and the foundation model compound together.
If you work in reproductive medicine, platforms, or the science of uterine biology — we'd like to hear from you.